ea0035p337 | Developmental Endocrinology | ECE2014
Kulahin Nikolaj
, Watson Christopher J.
, Sajid Waseem
, Schluckebier Gerd
, Kristensen Claus
, Andersen Asser Sloth
, Kristensen Ole
, Norrman Matthias
, Meyts Pierre De
, Brzozowski Andrzej Marek
The insulin signalling system including the insulin receptor tyrosine kinase (IRTK) is evolutionarily ancient. The Drosophila Melanogaster genome contains seven genes for insulin-like peptides (ILPs) that are expressed in neurosecretory cells in a highly tissue- and stage-specific pattern, DILP17. There is however only one IRTK (dIR). This system is important in the regulation of metabolism, growth, reproduction and lifespan. We reported in 2011 the crystal stru...